World Automation Congress © 2010 TSI Press
نویسندگان
چکیده
Although focal brain cooling has distinct power on suppressing epileptic seizures, the technological and physiological feasibility for therapeutic application still remains unknown. This paper addressed the issue of technical feasibility though the development of an implantable, thermoelectricallydriven cooling device. Chronic application of the device on the seizure focus in rats significantly suppressed seizure frequencies at 20°C that were associated with the improvement of neurological functions in comparison to those of non-cooling groups. Further, we intraoperatively applied the cooling device on the irritated epileptic foci of the intractably epileptic patients (n=6). The results potentially supported the therapeutic feasibility of hypothermal devices for the treatment of epilepsy.
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World Automation Congress © 2010 TSI Press
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